Endocrine Abstracts

The LRP5 gene is believed to be primarily associated with bone metabolism via Wnt signalling. The latter pathway, however, seems to control various other systems outside the skeleton. We identified the C/T (c.4037:A1330V) polymorphism in the LRP5 gene using a restriction analysis of the PCR product in a cohort of 165 white untreated pre-and post-menopausal women. In a subset of 84 post-menopausal women we analysed the association between the LRP5 genotype and circulatin...